Your R&D Booster Passionate by Science

It is crucial to identify specific surrogate markers that reflect the drug’s mechanism of action (MoA), which can be utilized to monitor drug activity in both preclinical and clinical trials. By studying the drug’s impact on key biological pathways and identifying molecular markers of its activity, we provide critical insights to guide your development program. We focus in elucidating the precise molecular mechanism underlying your drug’s action.

The aim is to establish the fundamental scientific principles behind your project and your drug’s action. We excel in testing the scientific rationale of your candidate by linking its mechanism of action (MoA) to the disease’s biology. The outcome is a validation of your candidate MoA to establish the fundamentals of your project.

Proving the potential of your lead compound is crucial to determining if it can achieve the intended biological effect. These studies use in vitro models that replicate the targeted pathophysiology and biological processes. Our expertise in expediting the preclinical stage lies in selecting optimal experimental models tailored to the relevant pathophysiological and biological processes for your indication. Throughout these studies, we validate your lead compound’s efficacy with customized read-outs, fully demonstrating your candidate’s potential.

Relevance refers to the applicability of the preclinical models and findings to human diseases. This step implies an experimental system used to appropriately mimic the human condition that the drug aims to treat and to test its therapeutic effects against the standard of care. We specialize in comparative efficacy studies, safety evaluations, and biomarker monitoring to ensure that findings from animal models are effectively translated to human disease conditions.